Model No: JT00047
Trimethyl orthoformate
Trimethyl orthoformate is a high-purity chemical with excellent solubility. Widely used in pharmaceuticals, agrochemicals & coatings, it delivers reliable performance for industrial applications.
minimum order :
1 kilogram
Supply Ability :
100Tkilogram / Week
Stock Time :
30Day
Country of Origin :
China
Quantity :
US $1.03 - US $2.34 / kilogram
| CAS NO. | 149-73-5 |
| Chroma(APHA)：≤ | 20 |
| Content %：≥ | 99.0 |
| Methyl alcohol %：≤ | 0.45 |
| Methyl Formate%：≤ | 0.25 |
| Impurity%:：≤ | 0.25 |
| Boiling Point（℃）： | 103-105 |
| Densuty（20℃）： | 0.967-0.971 |
Main Applications
1. Pharmaceutical Intermediate Synthesis
- Trimethyl orthoformate (TMOF), also referred to as Methyl orthoformate in specific application scenarios, is among the preferred reagents for constructing key heterocyclic structures in medicinal chemistry. It possesses excellent reactivity and selectivity, making it indispensable in the synthesis of innovative drugs and pharmaceutical intermediates. Pharmaceutical manufacturers rely on high-purity Trimethyl orthoformate to ensure the quality and efficacy of drug intermediates.
- Synthesis of Vitamins and Antibiotics: Trimethyl orthoformate is an important starting material for the synthesis of classic drugs such as Vitamin B1 and sulfonamides. Its stable chemical properties enable precise control of reaction processes, while its high purity ensures the absence of harmful impurities in the final pharmaceutical products. Utilizing it in these syntheses significantly improves product yields and reduces production costs.
- Construction of Pyrimidine Nucleoside Antiviral Drugs: In the synthesis of antiherpesvirus drugs such as acyclovir and ganciclovir, Trimethyl orthoformate (TMOF) is used to construct their core pyrimidine ring structure—this is a key area of our service. It enhances the efficiency of ring formation reactions, and our high-quality Trimethyl orthoformate guarantees the structural integrity and biological activity of these antiviral drugs.
- Synthesis of Other Heterocyclic Compounds: Trimethyl orthoformate is widely used in the synthesis of various biologically active heterocyclic structures such as pyrazoles and isoxazoles. These structures are common pharmacophores in modern drug development. Its versatility allows it to adapt to diverse synthetic routes, supporting the development of new drugs with novel mechanisms of action.
2. Pesticide Chemistry
- Trimethyl orthoformate (TMOF) also plays a crucial role in the production of agrochemicals. Its unique formylation properties make it essential for synthesizing highly effective and low-toxicity pesticides, meeting the growing demand for environmentally friendly agricultural products.
- Synthesis of Pyrethroid Insecticides: As a key formylation reagent, Trimethyl orthoformate (TMOF) is used as an intermediate in the synthesis of mainstream low-toxicity insecticides such as lambda-cyhalothrin and deltamethrin. Its excellent solubility and reactivity ensure efficient synthesis processes, improving reaction efficiency and product purity. The application of Trimethyl orthoformate ensures that pyrethroid insecticides have strong insecticidal activity while minimizing environmental impact.
- Synthesis of Herbicides and Fungicides: Trimethyl orthoformate is used to construct the molecular skeletons of triazole and pyrimidine herbicides and fungicides, helping to improve crop protection. Its ability to form stable cyclic structures enhances the efficacy and persistence of these pesticides, while ensuring uniform reaction conditions. Our Trimethyl orthoformate products support the production of high-quality herbicides and fungicides that effectively control weeds and plant diseases.
3. Dyes and Photosensitive Materials
- Trimethyl orthoformate (TMOF) and Methyl orthoformate are important raw materials for the synthesis of various cyanine dyes. Their formylation reactivity is crucial for forming the conjugated structures that give cyanine dyes their unique optical properties. Manufacturers of dyes and photosensitive materials depend on high-purity Trimethyl orthoformate and Methyl orthoformate to ensure consistent color performance and light stability of their products.
- Cyanine Dye Synthesis: In the fields of photographic photosensitive materials, optical disc storage media, and some laser dyes, Trimethyl orthoformate (TMOF) is an indispensable formylation component for the synthesis of these functional dyes. Methyl orthoformate, as a co-reagent with Trimethyl orthoformate, optimizes the synthesis process by adjusting reaction rates and improving product solubility. Trimethyl orthoformate and Methyl orthoformate enable the production of cyanine dyes with excellent light absorption and emission properties, meeting the requirements of high-precision optical applications.
4. As a Protecting Group in Organic Synthesis
- In complex multi-step synthesis, protecting specific functional groups is a common strategy, and Trimethyl orthoformate (TMOF) and Methyl orthoformate excel in this application. Their ability to form stable protective groups ensures that target functional groups are not affected during subsequent reactions, supporting the synthesis of complex organic molecules.
- Carbonyl Protection: Trimethyl orthoformate (TMOF) can react with aldehydes to form dimethyl acetal, thereby protecting the aldehyde group from being affected in subsequent oxidation, reduction, or Grignard reactions. Methyl orthoformate, with its similar chemical properties, can also be used for carbonyl protection in specific synthesis scenarios. After the reaction is complete, the protecting group formed by Trimethyl orthoformate or Methyl orthoformate can be hydrolyzed under mild acidic conditions, ensuring the integrity of the target molecule. The reliability of Trimethyl orthoformate and Methyl orthoformate in protecting group applications makes them a preferred choice for organic chemists.
- Our high-purity Trimethyl orthoformate and Methyl orthoformate products meet global industrial standards, with guaranteed batch consistency and stable performance. Whether you need Trimethyl orthoformate for pharmaceutical synthesis, Methyl orthoformate for pesticide production, or both for dye manufacturing, we provide reliable supply and professional technical support. Contact us today to inquire about Trimethyl orthoformate and Methyl orthoformate product specifications, pricing, and customized supply solutions!
