Model No: JT00046
Triethyl Orthoformate
Triethyl orthoformate is a colorless. It is readily soluble in organic solvents such as ethanol and diethyl ether, but insoluble in water. Its core applications are as a condensing agent and protecting agent in organic synthesis, used in the preparation of pharmaceuticals, dyes, and fragrances.
minimum order :
1 kilogram
Supply Ability :
100Tkilogram / Week
Stock Time :
30Day
Country of Origin :
China
Quantity :
US $1.03 - US $2.30 / kilogram
CAS NO. | 122-51-0 |
Chromaticity (APHA): ≤ | 10 |
Appearance | Colorless, transparent liquid |
Content % ≥ | 99.0 |
Odor | With a slight ether-like odor |
Applications | A condensing agent and protecting agent in organic synthesis |
Boiling point | 143-146℃ |
Melting point | -76℃ |
Chemical formula | C7H16O3 |
Main Applications
1. Pharmaceutical Synthesis
As a key builder of drug molecular skeletons, Triethyl Orthoformate is a core intermediate in the synthesis of many important drugs. Triethyl Orthoformate’s unique molecular structure enables the construction of critical functional groups, making Triethyl Orthoformate irreplaceable in pharmaceutical R&D and production.
Antimalarial Drugs: In the synthesis of the classic drug chloroquine and its derivatives, Triethyl Orthoformate is a key component in the formation of the pyrimidine ring. Triethyl Orthoformate ensures the structural integrity of these drugs, directly impacting their antimalarial efficacy and bioavailability.
Vitamin Manufacturing: In the industrial production of vitamin B1 (thiamine), Triethyl Orthoformate participates in the synthesis of an important intermediate. Triethyl Orthoformate’s high reactivity and selectivity guarantee the high yield and purity of vitamin B1, meeting strict food and pharmaceutical standards.
Antibiotics and Antiviral Drugs: Triethyl Orthoformate is widely used in the synthesis of various quinolone antibiotics and nucleoside antiviral drugs. Triethyl Orthoformate facilitates the formation of the core heterocyclic structures of these drugs, enhancing their ability to target pathogenic bacteria and viruses.
2. Pesticide Manufacturing
In the world of agrochemicals, Triethyl Orthoformate is the"unsung hero"in the synthesis of highly effective, low-toxicity pesticides. Triethyl Orthoformate’s versatility allows it to participate in multiple reaction pathways, making Triethyl Orthoformate a staple in modern pesticide formulations.
Pyrethroid Insecticides: As a key etherifying agent, Triethyl Orthoformate is used in the synthesis of mainstream insecticides such as cypermethrin and lambda-cyhalothrin. Triethyl Orthoformate improves the stability and insecticidal activity of these products, ensuring they effectively control pests while minimizing environmental impact.
Triazole Fungicides: Triethyl Orthoformate plays an important role in the construction of core structures such as the triazole ring. Triethyl Orthoformate enables the synthesis of high-performance fungicides that protect crops from fungal infections, boosting agricultural yields and quality.
3. Dye and Pigment Industry
Triethyl Orthoformate is an important raw material for the synthesis of various cyanine dyes. Triethyl Orthoformate contributes to the formation of the conjugated double bond systems that give cyanine dyes their vivid hues, making Triethyl Orthoformate a key driver of color innovation in the dye industry. These dyes are widely used due to their vibrant colors and excellent optical properties in:
Photographic materials
Laser printing
Textile dyeingTriethyl Orthoformate ensures the dyes have strong light fastness and color fastness, making them suitable for long-term use in various applications.
4. Other Fine Chemical Applications
The uses of Triethyl Orthoformate extend far beyond this; Triethyl Orthoformate is also a versatile agent that supports multiple fine chemical processes:
Organic Synthesis Reagent: As a powerful dehydrating agent and an introduction reagent for ethoxymethyl (EOM) protecting groups, Triethyl Orthoformate is crucial in protecting sensitive functional groups (such as hydroxyl groups) in complex multi-step synthesis. Triethyl Orthoformate’s mild reaction conditions ensure the preservation of other functional groups, improving the overall efficiency of organic synthesis.
Fragrance Synthesis: Triethyl Orthoformate is used to manufacture certain fragrance molecules with specific aroma profiles. Triethyl Orthoformate helps create the unique chemical structures that produce pleasant scents, making Triethyl Orthoformate a valuable ingredient in the perfume and flavor industry.
